Ultimate Guide to Defeating Zandar (Lygus) in Honkai Star Rail

Ultimate Guide to Defeating Zandar (Lygus) in Honkai Star Rail

Updated: August 13,2025 | Game: HONKAI STAR RAIL
Ultimate Guide to Defeating Zandar (Lygus) in Honkai Star Rail

Honkai Star Rail has recently launched its 3.5 mission, introducing players to one of its most formidable challenges yet: the 'First Genius, Entelechy, Zandar,' also known as Lygus. Facing Zandar can be an intimidating prospect, but with the right strategies, you can overcome this boss and emerge victorious.

Zandar Boss Fight Mechanics Explained

Zandar's complexity as a boss arises from his diverse move set. Each of his abilities requires careful observation and reaction. Here’s an overview of Zandar’s moves:

Move NameExplanation
Summon and HealZandar can summon mythical enemies and heal them on his turn.
Mode ChangeZandar’s mode changes, increasing damage received during a switch.
Evolution ModeZandar’s base mode. Summoning more enemies hastens mode changes.
Antinomy StateRecharges Ultimate for a random ally, who takes 50% max HP damage if used.
Disputation ModeZandar prepares his Ultimate attack and takes increased damage here.
Query: Prime Mover’s OutcomeZandar’s ultimate ability that inflicts massive AoE damage.

How to Defeat Lygus AKA Zandar Boss in Honkai Star Rail

Armed with knowledge about Zandar’s mechanics, you are now poised to strategize your approach for the battle. Selecting appropriate characters is essential for triumphing over Zandar. Below are the key strategies you should implement:

Best Characters for Zandar Boss Fight

As Zandar changes his state rapidly according to the battlefield dynamics, selecting the right characters can make a huge difference. It’s advisable to choose characters that deal Ice, Physical, or Wind damage. Here’s a list of characters best suited for this boss fight:

DPSSupportSustain
HysilensRuan MeiLingsha
PhainonRobinAventurine
The HertaTribbieGallagher
BladeJadeNatasha
ArgentiPelaFu Xuan
JingliuBronyaGeopard
Black SwanSundayHuohuo
SaberTingyun

Some recommended team compositions include:

  • The Herta Hypercarry: The Herta, Jade, Ruan Mei, Lingsha
  • Phainon Hypercarry: Phainon, Sunday, Bronya, Tingyun
  • Argenti Hypercarry: Argenti, Jade, Ruan Mei, Lingsha
  • Hysilens Stacked DoT: Hysilens, Kafka, Black Swan, Gallagher

Choosing any of these configurations will significantly enhance your chances of defeating Zandar.

Counter Zandar’s Boss Mechanics

To effectively counter Zandar’s mechanics, follow these tips:

  • Do not utilize the Ultimate triggered from the Antinomy State effect unless you’re playing as Phainon; the max HP penalty is not worth it for other characters.
  • Swiftly eliminate his summoned enemies during the Disputation Mode to mitigate damage from his Ultimate.
  • Avoid characters with Memosprites; if necessary, limit to one character only.

With these strategies, you'll be well on your way to conquering Zandar in Honkai Star Rail. For additional resources or if you have any questions regarding the boss guide, feel free to comment below!

For those looking to bolster their gameplay experience in Honkai Star Rail, consider checking out Honkai Star Rail Top Up for valuable resources!