Best Poison Spiritborn Leveling Build in Diablo 4 Season 10

Best Poison Spiritborn Leveling Build in Diablo 4 Season 10

Updated: October 06,2025 | Game: DIABLO 4
Best Poison Spiritborn Leveling Build in Diablo 4 Season 10

Diablo 4 Poison Spiritborn Leveling Build

In the ever-evolving landscape of Diablo 4, the Centipede skills for the Spiritborn have undergone significant buffs since their introduction, leading to the emergence of potent builds that excel in both the leveling and endgame phases. This guide focuses on a Poison-based build designed to unleash devastating damage in rapid succession, capable of clearing rooms swiftly and efficiently.

Embrace this Centipede Spiritborn leveling build in Season 10 to navigate through the pre-Torment phase with minimal effort. While it may take a while to reach its full potential, once it does, your gaming experience will elevate dramatically.

Active Skills

Skill

Description/Notes

Sharp Withering Fist (1/5)

Your ultimate Vigor generator, this skill excels in spreading Poison and clearing out lesser foes. Use it to punch through waves of enemies while obliterating your targets.

Advantageous Stinger (5/5)

With a substantial damage boost in Season 10, this Core skill is essential for the build. Opt for the Advantageous upgrade to enhance healing and apply Vulnerable status.

Measured Soar (1/5)

A fantastic movement skill, the Enhanced upgrade ensures crits or added movement speed when striking enemies. Use it to navigate quickly and dodge attacks.

Reinforced Scourge (1/5)

Your primary Defensive skill, which grants valuable breathing room. The Reinforced upgrade will also restore Vigor.

Invasive Touch of Death (5/5)

Deals tremendous Poison damage, spawning swarms of attacks upon defeating its target. Upgrading this skill allows for Poison spread beyond the screen's limits.

Exalted The Devourer (5/5)

This Ultimate skill capitalizes on Season 10 buffs to deal immense damage, perfect for big Elite groups and bosses.

Passive Skills

Skill

Description/Notes

Vigorous (3/3)

Core Skills will enhance Vigor generation.

Velocity (3/3)

Increased Vigor generation through movement.

Balanced Exertion (3/3)

Core Skills deal increased damage at the expense of more Vigor consumption.

Focal Point (3/3)

Grants bonus stats based on weapon type used.

Follow Through (3/3)

Boosts damage from Basic skills, especially on the third cast.

Apex (3/3)

Increases Vulnerable damage, further amplified against Elites.

Diminishment (3/3)

Vulnerable enemies will deal reduced damage to you.

Endurance (3/3)

Gaining Vigor upon casting a Defensive skill.

Antivenom (1/3)

Enhance Poison resistance and max Poison resistance stats.

Nourishment (3/3)

Increased healing boosts Poison damage when receiving healing.

Vehemence (3/3)

Potency skills increase in damage, but with longer cooldowns.

Resolution (1/3)

Enabling damage increases against Elites upon casting an Ultimate, doubling this bonus for bosses.

Sustenance (1/3)

Self-healing when hitting enemies with Ultimate skills.

Intricacy (1/3)

Last skill casts can be reset when using an Ultimate skill, with benefits in the following seconds.

Noxious Resonance

Critical hits on Poisoned enemies cause them to burst, transferring damage to nearby foes increased by 300% of remaining Poison damage.

Notably, Noxious Resistance significantly amplifies this build's effectiveness into the late game. Rather than waiting for enemies to succumb to Poison, you can effectively detonate their Poison damage by landing critical strikes. Thus, this becomes a vital ability for significantly increasing your damage output.

When utilizing this build, maximize your abilities and be strategic about usage, reserving Scourge and Devourer for critical instances while employing other skills as necessary.

For effective leveling, initiate on Normal difficulty, progressing to Hard by level 10. Once you gain Noxious Resonance, increase to Expert difficulty. Prioritize maxing out Stinger first, then allocate points into each active skill before focusing on passives.

Spirit Hall Bonuses

Select Centipede as your main Spirit Hall bonus, amplifying your Poison damage output and reducing enemy damage dealt through Slowing effects. For your secondary bonus, utilize Eagle, ensuring that every second ability cast (including Withering Fist) results in a critical strike—which paves the way for smoother leveling from level 30 to 60, freeing you from the need for heavy crit chance stacking initially. With sufficient crit chance later, swapping out Eagle for Jaguar can increase your Attack Speed.

Chaos Powers

In Diablo 4 Season 10, Chaos Powers were introduced, allowing characters to obtain additional abilities, either passively or to enhance existing skills. For this build, consider utilizing the following:

  • Accelerating Chaos (Common): An enemy hit may trigger an instant cooldown reduction through a Lucky Hit.
  • Alacrity (Common): This aspect speeds up Basic Skills significantly, with improved Dash range and reduced casting intervals.
  • Crazy Brew (Legendary): Gain Resource Cost Reduction and enhancements to Attack and Movement Speeds following a Healing Potion use.
  • Convocation of Spirits (Unique): Non-Ultimate skill casts may invoke benefits pertaining to their respective skills based on the player’s Ultimate Skill Damage stat.

Gear and Stat Priority

Best Items for Centipede Spiritborn in Diablo 4

Sticking with Poison as your primary damage source, steer clear of Critical Strike Damage. Concentrate instead on Damage Over Time and Poison Damage. Despite Noxious Resonance's interactions with Critical Strikes, conventional crit damage won't be beneficial to Poison attacks.

Focus your gear on acquiring the following stats:

  • Damage Over Time
  • Poison Damage
  • Overall Damage
  • Dexterity
  • Critical Strike Chance
  • Attack Speed
  • Cooldown Reduction
  • Defensive Stats (Life, Armor, Resistances)
  • Movement Speed
  • Ranks to Stinger
  • Ranks to Nourishment

Legendary Aspects

Item

Aspect

Helmet

Aspect Of The Protector

Chest

Aspect Of Might

Gloves

Aspect of Infestation

Pants

Aspect of the Prudent Heart

Boots

Aspect of Haste

Amulet

Aspect of Binding Morass

Rings

  • Aspect of Adaptability
  • Rapid Aspect

2H Weapon (preferably Glaive)

Aspect of Pestilence

Aspects of Pestilence, Infestation, and Binding Morass are designed to significantly enhance your damage output, while remaining aspects will provide necessary defensive support and utility. Some aspects can be unlocked via dungeons, yet for others, legendary item farming will be needed to ultimately integrate them into your Codex of Power.

Paragon Boards

While leveling builds don't heavily rely on Paragon Boards, the following board strategies can help immensely:

  • Bane Glyph: Must-have for Poison builds; level it up to enhance its effectiveness.
  • Bitter Medicine: Follow this board path towards its rewards.
  • Sapping and Revealing: Implement these boards for later game power boosts based on your condition.

As you encounter challenges in higher Torment difficulties, seek Paragon nodes that boost survivability. Conversely, if dying isn’t an issue, focus entirely on damage-enhancing nodes.

For those looking to buy unique items in Diablo 4 or want cheap Diablo 4 items, make sure to browse through reliable sources to equip your character with the best gear available. With the right strategies, you’ll dominate every encounter.